From the Camarillo Brain Study Project decades ago, this is the result of 5 hour glucose tolerance tests administered to mental hospital patiens with advanced Alzheimer’s disease. In the age group 75-84, the blood glucose values reached a peak of 215 mg% only after 2 hours and did not return to fasting levels even at 5 hours. This seems likely to reflect impaired capacity of the entire body for glucose utilization.
After decades of conflicting research on the development of this metabolic defect prior to dementia, a recent study has made major progress in filling the gap.Glucose Tolerance Status and Risk of Dementia in the Community: T.Ohara et al. , Neurology, 2011, Sept. 20.
This is a 15 year study of glucose tolerance tests in 1017 persons who were initially free of dementia. It was found that most, if not all, persons who developed Alzheimer’s disease had elevated 2 hour blood glucose levels while fasting levels were not elevated. This supports the writer’s view that Alzheimer’s disease is a generalized impairment in glucose utilization . A progressive elevation of the 2 hour blood glucose with normal fasting levels may be the first clinical manifestation of the disease and this may be identified many years prior to dementia.
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Tags: Alzheimer causation
